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Reference
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| Citation |
McGinnis, N., Ragnhildstveit, E., Veraksa, A., McGinnis, W. (1998). A cap 'n' collar protein isoform contains a selective Hox repressor function. Development 125(22): 4553--4564. |
| FlyBase ID |
FBrf0105883 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9778513 |
| PubMed Abstract |
We have characterized a protein isoform (CncB) from the Drosophila cap 'n' collar locus that selectively represses cis-regulatory
elements that are activated by the Hox protein Deformed. Of the three Cnc protein isoforms, CncB is expressed in a localized
pattern in mandibular and labral cells of the head during mid-stages of embryogenesis. When CncB protein is absent or reduced,
mandibular cells are homeotically transformed toward maxillary identities. This transformation is associated with persistent
Deformed expression in anterior mandibular cells, since the Deformed autoactivation circuit is normally antagonized by CncB
function in these cells. Heat-shock-induced ectopic expression of CncB in mid-stages of embryogenesis is sufficient to attenuate
the activity of Dfd response elements in maxillary epidermal cells, but appears to have no effect in trunk epidermal cells
on either the function or the response elements of other Hox proteins. CncB provides a mechanism to modulate the specificity
of Hox morphogenetic outcomes, which results in an increase in the segmental diversity in the Drosophila head.
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| Biosis |
1999.59412 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Development |
| Title |
Development |
| Authors |
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| Volume range |
99- |
| Year range |
1987- |
| Page range |
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| Publisher |
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| Place of publication |
Cambridge |
| Language of publication |
English |
| ISBN/ISSN |
0950-1991 |
| CODEN |
DEVPED |
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Data from Reference
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| Alleles (14)
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| Constructs (9)
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| Genes (5)
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