Reference Report

Reference
Citation	Michelson, A.M., Gisselbrecht, S., Buff, E., Skeath, J.B. (1998). Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila. Development 125(22): 4379--4389. (Export to RIS)
FlyBase ID	FBrf0105885
Publication Type	Research paper
PubMed ID	9778498
PubMed Abstract	Drosophila possesses two FGF receptors which are encoded by the heartless and breathless genes. HEARTLESS is essential for early migration and patterning of the embryonic mesoderm, while BREATHLESS is required for proper branching of the tracheal system. We have identified a new gene, heartbroken, that participates in the signalling pathways of both FGF receptors. Mutations in heartbroken are associated with defects in the migration and later specification of mesodermal and tracheal cells. Genetic interaction and epistasis experiments indicate that heartbroken acts downstream of the two FGF receptors but either upstream of or parallel to RAS1. Furthermore, heartbroken is involved in both the HEARTLESS- and BREATHLESS-dependent activation of MAPK. In contrast, EGF receptor-dependent embryonic functions and MAPK activation are not perturbed in heartbroken mutant embryos. A strong heartbroken allele also suppresses the effects of hyperactivated FGF but not EGF receptors. Thus, heartbroken may contribute to the specificity of developmental responses elicited by FGF receptor signalling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3R)ry506-85C
Alleles (16)
	bnl^Scer\UAS.cSa btl::Egfr^{Scer\UAS.T:λ\cI-DD} btl^H82Δ3 btl^LG19 dpp^Scer\UAS.cSa htl^AB42 htl^{Scer\UAS.T:λ\cI-DD} htl^YY262 Ras85D^{G13Q.Scer\UAS} Scer\GAL4^69B Scer\GAL4^twi.PG stumps^ems6 stumps^ems7 stumps^YY202 T:λ\cI^DD w^+mC
Constructs (6)
	P{GAL4-twi.G} P{UAS-bnl.S} P{UAS-dpp.S} P{UAS-Egfr.λtop} P{UAS-htl.λ\cI.M} P{UAS-Ras85B.Act}
Genes (17)
	bap bnl btl btl::Egfr dpp eve Fas3 htl Mef2 Mhc Ras85D rl Scer\GAL4 stumps T:λ\cI twi w
Insertions (1)
	P{GawB}69B