Reference Report

Reference
Citation	Murray, M.J., Merritt, D.J., Brand, A.H., Whitington, P.M. (1998). In vivo dynamics of axon pathfinding in the Drosophila CNS: a time-lapse study of an identified motorneuron. J. Neurobiol. 37(4): 607--621. (Export to RIS)
FlyBase ID	FBrf0105890
Publication Type	Research paper
PubMed ID	9858262
PubMed Abstract	We developed a system for time-lapse observation of identified neurons in the central nervous system (CNS) of the Drosophila embryo. Using this system, we characterize the dynamics of filopodia and axon growth of the motorneuron RP2 as it navigates anteriorly through the CNS and then laterally along the intersegmental nerve (ISN) into the periphery. We find that both axonal extension and turning occur primarily through the process of filopodial dilation. In addition, we used the GAL4-UAS system to express the fusion protein Tau-GFP in a subset of neurons, allowing us to correlate RP2's patterns of growth with a subset of axons in its environment. In particular, we show that RP2's sharp lateral turn is coincident with the nascent ISN.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurobiol.
Title	Journal of Neurobiology
Publication Year	1969-
ISBN/ISSN	0022-3034
Data from Reference
Alleles (3)
	Avic\GFP^{Scer\UAS.S65T.I167T.T:Btau\MAPT} Scer\GAL4^ftz.ng w^+mC
Constructs (2)
	P{GAL4-ftz.ng} P{UAS-Tau-GFP.S65T.I167T}
Genes (5)
	Avic\GFP Btau\MAPT Scer\GAL4 T:Btau\MAPT w