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Citation
Simmonds, A.J., Liu, X., Soanes, K.H., Krause, H.M., Irvine, K.D., Bell, J.B. (1998). Molecular interactions between vestigial and scalloped promote wing formation in Drosophila.  Genes Dev. 12(24): 3815--3820.
FlyBase ID
FBrf0105934
Publication Type
Research paper
Abstract

Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a tissue-specific transcriptional intermediary factor of Sd.

PubMed ID
PubMed Central ID
PMC317270 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (9)
    Genes (9)
    Physical Interactions (6)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (5)