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Citation
Thackeray, J.R., Gaines, P.C., Ebert, P., Carlson, J.R. (1998). small wing encodes a phospholipase C-() that acts as a negative regulator of R7 development in Drosophila.  Development 125(24): 5033--5042.
FlyBase ID
FBrf0105946
Publication Type
Research paper
Abstract

Phospholipase C-(gamma) (PLC-(gamma)) is activated in many cell types following growth factor stimulation. Our understanding of the role of PLC-(gamma) in cell growth and differentiation has been severely limited by the dearth of mutations in any organism. In this study, we show that the Drosophila gene small wing (sl), identified by Bridges in 1915, encodes a PLC-(gamma). Mutations of sl result in extra R7 photoreceptors in the compound eye, consistent with overactivation of the receptor tyrosine kinase pathways that control R7 development. The data presented here provide the first genetic evidence that PLC-(gamma) is involved in Ras-mediated signaling and indicate that PLC-(gamma) acts as a negative regulator in such pathways in Drosophila.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (3)
    Alleles (10)
    Gene Groups (2)
    Genes (7)
    Insertions (1)
    Transgenic Constructs (1)