Reference Report

Reference
Citation	Van Doren, M., Broihier, H.T., Moore, L.A., Lehmann, R. (1998). HMG-CoA reductase guides migrating primordial germ cells. Nature 396(6710): 466--469. (Export to RIS)
FlyBase ID	FBrf0105951
Publication Type	Research paper
PubMed ID	9853754
PubMed Abstract	The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is best known for catalysing a rate-limiting step in cholesterol biosynthesis, but it also participates in the production of a wide variety of other compounds. Some clinical benefits attributed to inhibitors of HMG-CoA reductase are now thought to be independent of any serum cholesterol-lowering effect. Here we describe a new cholesterol-independent role for HMG-CoA reductase, in regulating a developmental process: primordial germ cell migration. We show that in Drosophila this enzyme is highly expressed in the somatic gonad and that it is necessary for primordial germ cells to migrate to this tissue. Misexpression of HMG-CoA reductase is sufficient to attract primordial germ cells to tissues other than the gonadal mesoderm. We conclude that the regulated expression of HMG-CoA reductase has a critical developmental function in providing spatial information to guide migrating primordial germ cells.
DOI
Related Publication(s)
Review	Paper alert. Jones, 1999, Curr. Opin. Genet. Dev. 9(1): 5 [FBrf0106722]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (9)
	Hmgcr⁰¹¹⁵² Hmgcr^clb1 Hmgcr^clb2 Hmgcr^{Scer\UAS.cvDa} Scer\GAL4^69B Scer\GAL4^elav-C155 Scer\GAL4^h-1J3 Scer\GAL4^{nos.UTR.T:Hsim\VP16} w^+mC
Constructs (2)
	P{GAL4::VP16-nos.UTR} P{UAS-Hmgcr.vD}
Genes (7)
	eya Hmgcr Scer\GAL4 T:Hsim\VP16 vas w wun
Insertions (4)
	P{GawB}69B P{GawB}elav^C155 P{GawB}h^1J3 P{PZ}Hmgcr⁰¹¹⁵²