HomeReference Report
| Reference | |
|---|---|
| Citation | Noordermeer, J.N., Kopczynski, C.C., Fetter, R.D., Bland, K.S., Chen, W.Y., Goodman, C.S. (1998). Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila. Neuron 21(5): 991--1001. |
| FlyBase ID | FBrf0106021 |
| Type of publication | Research paper |
| Offprint Available | Yes |
| External Crossreferences | |
| PubMed ID | 9856456 |
| PubMed Abstract | The midline glia are specialized, nonneuronal cells at the midline of the Drosophila central nervous system (CNS). During development, the midline glia provide guidance cues for extending axons. At the same time, they migrate and help separate the two axon commissures. They then wrap around and ensheath the commissural axons. In many segments, a few of the glia do not enwrap the axons, and these cells die. The wrapper gene encodes a novel member of the immunoglobulin (Ig) superfamily. Wrapper protein is expressed specifically on the surface of midline glia. In wrapper mutant embryos, the midline glia express their normal guidance cues and migrate normally. However, they do not ensheath the commissural axons, and as a result, the glia die. In the absence of Wrapper, the two axon commissures are not properly separated. |
| Biosis | 1999.46556 |
| Zoological record | |
Associated Information
|
|
| Comments | |
| Text of personal communication | |
| Associated files | |
|
Related Publications
|
|
| Review | Paper alert. Anonymous, 1999, Curr. Opin. Neurobiol. 9(1): 2 [FBrf0112200] Paper alert. Filbin, 1999, Curr. Opin. Neurobiol. 9(1): 7 [FBrf0112203] |
|
Also Published As
|
|
|
Other Reference Information
|
|
| Secondary IDs | |
| Language of publication | English |
| Additional language(s) of abstract | |
| ISBN | |
| Place of publication | |
|
Published In
|
|
| Abbreviation | Neuron |
| Title | Neuron |
| Authors | |
| Volume range | 1- |
| Year range | 1988- |
| Page range | |
| Publisher | |
| Place of publication | Cambridge, MA |
| Language of publication | English |
| ISBN/ISSN | 0896-6273 |
| CODEN | NERNET |
|
Data from Reference
|
|
| Aberrations (3)
|
|
| Alleles (19)
|
|
| Constructs (3)
|
|
| Genes (7)
|
|
| Insertions (4)
|
|