Reference Report

Reference
Citation	Ye, Y., Fortini, M.E. (1998). Characterization of Drosophila Presenilin and its colocalization with Notch during development. Mech. Dev. 79(1,2): 199--211. (Export to RIS)
FlyBase ID	FBrf0106046
Publication Type	Research paper
PubMed ID	10349633
PubMed Abstract	Mutant Presenilin proteins cause early-onset familial Alzheimer's disease in humans and Caenorhabditis elegans Presenilins may facilitate Notch receptor signaling. We have isolated a Drosophila Presenilin homologue and determined the spatial and temporal distribution of the encoded protein as well as its localization relative to the fly Notch protein. In contrast to previous mRNA in situ studies, we find that Presenilin is widely expressed throughout oogenesis, embryogenesis, and imaginal development, and generally accumulates at comparable levels in neuronal and nonneuronal tissues. Double immunolabeling with Notch antibodies revealed that Presenilin and Notch are coexpressed in many tissues throughout Drosophila development and display partially overlapping subcellular localizations, supporting a possible functional link between Presenilin and Notch.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (2)
	Df(3L)rdgC-co2 Df(3L)ri-79c
Alleles (5)
	Psn^hs.PY Psn^Scer\UAS.cYa Psn^T:Hsap\MYC Scer\GAL4^en-e16E Scer\GAL4^hs.2sev
Constructs (2)
	P{GAL4-Hsp70.sev} P{UAS-PS.Y}
Genes (5)
	elav N Psn Scer\GAL4 T:Hsap\MYC
Insertions (1)
	P{en2.4-GAL4}e16E