Reference Report

Reference
Citation	Golembo, M., Yarnitzky, T., Volk, T., Shilo, B.Z. (1999). Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm. Genes Dev. 13(2): 158--162. (Export to RIS)
FlyBase ID	FBrf0106549
Publication Type	Research paper
PubMed ID	9925640
PubMed Abstract	The presence of a single EGF receptor in Drosophila is contrasted by multiple ligands activating it. This work explores the role of two ligands, Spitz and Vein, in the embryonic ventral ectoderm. Spitz is a potent ligand, whereas Vein is an intrinsically weak activating ligand. We show that secreted Spitz emanating from the midline, triggers expression of vein in the ventral-most cell rows, by inducing expression of the ETS domain transcription factor Pointed P1. In the absence of Vein, lateral cell fates are not induced when Spitz levels are compromised. The positive feedback loop of Vein generates a robust mechanism for patterning the ventral ectoderm.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (12)
	aop^ACT.Scer\UAS pnt^P1.Scer\UAS pnt^Δ88 rho^PΔ38 rho^Scer\UAS.cGa Scer\GAL4^69B Scer\GAL4^en-e16E Scer\GAL4^Kr.PM spi³ spi^s.Scer\UAS vn^L6 vn^Scer\UAS.cYa
Constructs (6)
	P{GAL4-Kr.C} P{UAS-aop.ACT} P{UAS-pnt.P1} P{UAS-spi.s} P{UAS-ve.(rho)G} P{UAS-vn.Y}
Genes (8)
	aop Fas3 oc pnt rho Scer\GAL4 spi vn
Insertions (2)
	P{en2.4-GAL4}e16E P{GawB}69B