Reference Report

Reference
Citation	Holmes, A.L., Heilig, J.S. (1999). Fasciclin II and beaten path modulate intercellular adhesion in Drosophila larval visual organ development. Development 126(2): 261--272. (Export to RIS)
FlyBase ID	FBrf0106663
Publication Type	Research paper
External Crossreferences
PubMed ID	9847240
PubMed Abstract	Previous studies demonstrated that Fasciclin II and Beaten path are necessary for regulating cell adhesion events that are important for motoneuron development in Drosophila. We observe that the cell adhesion molecule Fasciclin II and the secreted anti-adhesion molecule Beaten path have additional critical roles in the development of at least one set of sensory organs, the larval visual organs. Taken together, phenotypic analysis, genetic interactions, expression studies and rescue experiments suggest that, in normal development, secretion of Beaten path by cells of the optic lobes allows the Fasciclin II-expressing larval visual organ cells to detach from the optic lobes as a cohesive cell cluster. Our results also demonstrate that mechanisms guiding neuronal development may be shared between motoneurons and sensory organs, and provide evidence that titration of adhesion and anti-adhesion is critical for early steps in development of the larval visual system.
BIOSIS ID	1999.237936
Zoological Record ID	13510002416
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Editors
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)r10
Alleles (10)
	beat-Ia² beat-Ia³ beat-Ia^Scer\UAS.cFa beat-Ia^tric-1 Ecol\lacZ^gl-B172 Fas2^e76 Fas2^Scer\UAS.cHa Scer\GAL4^bi-omb-Gal4 Scer\GAL4^GMR.PF Scer\GAL4^Kr.PM
Constructs (4)
	P{GAL4-Kr.C} P{GAL4-ninaE.GMR} P{UAS-beat.F} P{UAS-Fas2.H}
Genes (5)
	beat-Ia Ecol\lacZ Fas2 Kr Scer\GAL4
Insertions (2)
	P{GAL4}bi^omb-Gal4 P{lacW}gl^B172