Open Close
Reference
Citation
Scott, J.G., Liu, N., Wen, Z. (1998). Insect cytochromes P450: diversity, insecticide resistance and tolerance to plant toxins.  Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 121(1-3): 147--155.
FlyBase ID
FBrf0107240
Publication Type
Review
Abstract
In the last decade, studies of individual insect P450s have blossomed. This new information has furthered our understanding of P450 diversity, insecticide resistance and tolerance to plant toxins. Insect P450s can be adult specific, larval specific or life stage independent. Similarly, insect P450s vary as to the tissues where they are expressed and in their response to inducers. Insect P450s can now be rapidly sequenced using degenerate PCR primers. Given the huge diversity represented by the Class Insecta, this technique will provide vast amounts of new information about insect P450s and the evolution of the P450 gene superfamily. CYP6D1 is responsible for monooxygenase-mediated resistance to pyrethroid insecticides in the house fly. CYP6D1 is ubiquitously expressed in adults with 10-fold higher levels found in the resistant strain compared to susceptible strains. CYP6D1 is on autosome 1 in house fly. The high level of expression found in the resistant strain is due to genes on autosomes 1 and 2. Whether or not the different CYP6D1 alleles found in resistant and susceptible strains have any role in resistance remains to be elucidated. The CYP6B gene subfamily is involved in the metabolism of host plant toxins (i.e. furanocoumarins). CYP6B gene transcripts in two Papilio (swallowtail) species have been shown to be induced by host plant toxins and in turn to metabolize these toxins. CYP6B P450s play a critical role in allowing Papilio to adapt to furanocoumarin-containing host plants. Similarities in structural and promoter regions of the CYP6B genes suggest that they are derived from a common ancestral gene. Although the P450 monooxygenases of insects are important for the metabolism of hormones and phermones, no individual P450 has yet been shown to metabolize an endogenous compound. Advances in this area are critical because they will provide important new information about insect physiology, biochemistry and development.
PubMed ID
PubMed Central ID
DOI
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol.
    Title
    Comparative Biochemistry and Physiology
    Publication Year
    1994-
    ISBN/ISSN
    1367-8280
    Data From Reference