Reference Report

Reference
Citation	Spencer, S.A., Powell, P.A., Miller, D.T., Cagan, R.L. (1998). Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125(23): 4777--4790. (Export to RIS)
FlyBase ID	FBrf0107294
Publication Type	Research paper
PubMed ID	9806926
PubMed Abstract	Developing epithelia use a variety of patterning mechanisms to place individual cells into their correct positions. However, the means by which pattern elements are established are poorly understood. Here, we report evidence that regulation of Drosophila EGF receptor (DER) activity plays a central role in propagating the evenly spaced array of ommatidia across the developing Drosophila retina. DER activity is essential for establishing the first ommatidial cell fate, the R8 photoreceptor neuron. R8s in turn appear to signal through Rhomboid and Vein to create a patterned array of 'proneural clusters' which contain high levels of phosphorylated ERKA and the bHLH protein Atonal. Finally, secretion by the proneural clusters of Argos represses DER activity in less mature regions to create a new pattern of R8s. Propagation of this process anteriorly results in a retina with a precise array of maturing ommatidia.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)γ3
Alleles (16)
	aos^hs.PSa aos^p1 Avic\GFP^Ubi-p63E.PD btl::Egfr^{Scer\UAS.T:λ\cI-DD} Ecol\lacZ^rho-AA69 Egfr^DN.Scer\UAS Egfr^E1 Ras85D^V12.hs rho⁶ rho^7M43 rho^a.hs rho^hs.PSt Scer\GAL4^hs.PB T:λ\cI^DD vn^ry vn^unspecified
Constructs (8)
	P{GAL4-Hsp70.PB} P{hs-argos.S} P{hsRas1.V12} P{hs-rho.a} P{HS-rho} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{Ubi-GFP.D}
Genes (15)
	aos ato Avic\GFP boss btl::Egfr E(spl)m8-HLH Ecol\lacZ Egfr Ras85D rho rl ro Scer\GAL4 T:λ\cI vn
Insertions (1)
	P{A92}rho^AA69