Reference Report

Reference
Citation	Vazquez, M., Moore, L., Kennison, J.A. (1999). The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. Development 126(4): 733--742. (Export to RIS)
FlyBase ID	FBrf0107412
Publication Type	Research paper
PubMed ID	9895321
PubMed Abstract	The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation. We report here that brm interacts with another trithorax group gene, osa, to regulate the expression of the Antennapedia P2 promoter. Regulation of Antennapedia by BRM and OSA proteins requires sequences 5' to the P2 promoter. Loss of maternal osa function causes severe segmentation defects, indicating that the function of osa is not limited to homeotic gene regulation. The OSA protein contains an ARID domain, a DNA-binding domain also present in the yeast SWI1 and Drosophila DRI proteins. We propose that the OSA protein may target the BRM complex to Antennapedia and other regulated genes.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (10)
	Df(3L)brm11 Df(3L)th102 Df(3R)RD31 In(3R)Antp^73b In(3R)Antp^B In(3R)Antp^CB In(3R)Antp^LC In(3R)Antp^R T(2;3)Antp¹⁷ Tp(3;2)Antp^Ctx
Alleles (42)
	Antp¹ Antp¹⁷ Antp²³ Antp^73b Antp^B Antp^CB Antp^Ctx Antp^hs.PHTA Antp^LC Antp^Ns Antp^R ash1⁶ brm¹ brm² brm⁵ brm^+t14.4 btl^dev1 btl^dev2 Glut4EF^Antp-B Glut4EF^Antp-R kis¹ kis² kto³ l(3)72Ab¹ mor¹ mor² osa¹ osa² osa³ osa⁴ osa⁵ osa⁶ osa¹¹ osa¹² osa⁰⁰⁰⁹⁰ skd² skd³ Snr1⁰¹³¹⁹ Trl³ Trl⁶² trx^E2 Vha55¹⁶
Constructs (2)
	P{BR14.4} P{hsp70-Antp}
Genes (15)
	Antp ash1 brm btl Glut4EF kis kto l(3)72Ab mor osa skd Snr1 Trl trx Vha55
Insertions (3)
	F{}Antp²³ P{}osa⁶ P{PZ}osa⁰⁰⁰⁹⁰