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Reference Report
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| Citation | Hamada, F., Tomoyasu, Y., Takatsu, Y., Nakamura, M., Nagai, S., Suzuki, A., Fujita, F., Shibuya, H., Toyoshima, K., Ueno, N., Akiyama, T. (1999). Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science 283(5408): 1739--1742. (Export to RIS) | ||
| FlyBase ID | FBrf0107755 | ||
| Publication Type | Review | ||
| PubMed ID | 10073940 | ||
| PubMed Abstract | Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Science | ||
| Title | Science | ||
| Publication Year | 1895- | ||
| ISBN/ISSN | 0036-8075 | ||
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Data from Reference
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| Alleles (7)
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| Constructs (1)
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| Genes (7)
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| Insertions (4)
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