Reference Report

Reference
Citation	Ito, N., Rubin, G.M. (1999). gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96(4): 529--539. (Export to RIS)
FlyBase ID	FBrf0107789
Publication Type	Research paper
PubMed ID	10052455
PubMed Abstract	Tuberous sclerosis complex (TSC) is an autosomal dominant disorder leading to the widespread development of benign tumors that often contain giant cells. We show that the Drosophila gene gigas encodes a homolog of TSC2, a gene mutated in half of TSC patients. Clones of gigas mutant cells induced in imaginal discs differentiate normally to produce adult structures. However, the cells in these clones are enlarged and repeat S phase without entering M phase. Our results suggest that the TSC disorder may result from an underlying defect in cell cycle control. We have also identified a Drosophila homolog of TSC1.
DOI
Related Publication(s)
Erratum	gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Ito and Rubin, 2001, Cell 105(3): 415 [FBrf0135686]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (8)
	Df(3L)rdgC-co2 Df(3L)ri-79c Df(3L)XS411 Df(3L)XS533 Df(3L)XS543 Df(3L)XS572 Df(3L)XS705 Df(3L)XS2182
Alleles (15)
	Ecol\lacZ^arm.PV gig^5C8 gig²⁵ gig⁵⁵ gig⁵⁶ gig⁵⁷ gig⁶² gig¹⁰⁹ gig¹⁹² gig¹⁹³ gig²⁰¹ gig²⁷³ gig⁰²²⁵³ gig^hs.PI w^+mC
Constructs (2)
	P{arm-lacZ.V} P{hs-gig.I}
Genes (8)
	cu CycA CycB Ecol\lacZ gig st Tsc1 w