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Citation
Jazwinska, A., Kirov, N., Wieschaus, E., Roth, S., Rushlow, C. (1999). The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.  Cell 96(4): 563--573.
FlyBase ID
FBrf0107795
Publication Type
Research paper
Abstract

decapentaplegic (dpp), a Drosophila member of the TGFbeta family of secreted molecules, functions as a long-range morphogen in patterning of the embryo and the adult appendages. Dpp signals via the SMAD proteins Mad and Medea. Here we show that in the absence of brinker (brk), Mad is not required for the activation of Dpp target genes that depend on low levels of Dpp. brk encodes a novel protein with features of a transcriptional repressor. brk itself is negatively regulated by Dpp. Dpp signaling might relieve brk's repression of low-level target genes either by transcriptional repression of brk or by antagonizing a repressor function of brk at the target gene promoters.

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PubMed Central ID
Related Publication(s)
Review

Paper alert.
Kudoh, 1999, Curr. Opin. Genet. Dev. 9(3): 256--257 [FBrf0108855]

Paper alert.
Kudoh, 1999, Curr. Opin. Cell Biol. 11(3): 296 [FBrf0110114]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (12)
    Genes (9)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (3)