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Citation
Nagaraj, R., Pickup, A.T., Howes, R., Moses, K., Freeman, M., Banerjee, U. (1999). Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial.  Development 126(5): 975--985.
FlyBase ID
FBrf0107900
Publication Type
Research paper
Abstract

Growth and patterning of the Drosophila wing disc depends on the coordinated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in the wing pouch. We propose that a short-range signal originating from the core of the D/V boundary cells is responsible for activating EGFR in a zone of organizing cells on the edges of the D/V boundary. Using loss-of-function mutations and ectopic expression studies, we show that EGFR signaling is essential for vestigial transcription in these cells and for making them competent to undergo subsequent vestigial-mediated proliferation within the wing pouch.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference