Reference Report

Reference
Citation	Dong, X., Tsuda, L., Zavitz, K.H., Lin, M., Li, S., Carthew, R.W., Zipursky, S.L. (1999). ebi regulates epidermal growth factor receptor signaling pathways in Drosophila. Genes Dev. 13(8): 954--965. (Export to RIS)
FlyBase ID	FBrf0108171
Publication Type	Research paper
PubMed ID	10215623
PubMed Abstract	ebi regulates the epidermal growth factor receptor (EGFR) signaling pathway at multiple steps in Drosophila development. Mutations in ebi and Egfr lead to similar phenotypes and show genetic interactions. However, ebi does not show genetic interactions with other RTKs (e.g., torso) or with components of the canonical Ras/MAP kinase pathway. ebi encodes an evolutionarily conserved protein with a unique amino terminus, distantly related to F-box sequences, and six tandemly arranged carboxy-terminal WD40 repeats. The existence of closely related proteins in yeast, plants, and humans suggests that ebi functions in a highly conserved biochemical pathway. Proteins with related structures regulate protein degradation. Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	Df(2L)al
Alleles (21)
	ebi^1-334.GMR ebi^+t7.5 ebi^E4 ebi^E90 ebi^hs.PD ebi^k16213 ebi^P7 ebi^P25 Egfr::tor^{t4021E.hs.sev} Egfr^f2 Egfr^t1 phyl^GMR.PC rux³ Scer\FLP1^ey.PB sev::tor^13D.hs.sev sev⁶ Sos^34Ea-6 Sos^JC2 ttk¹ ttk⁰⁰²¹⁹ w^+mC
Constructs (7)
	P{ebi-7.5.D} P{ey-FLP.B} P{GMR-ebi.1-334} P{GMR-phyl} P{hs-ebi.D} P{sE-torso⁴⁰²¹-DER} P{sE-torso⁴⁰²¹-sev}
Genes (18)
	ebi Egfr Egfr::tor Fas3 hkb oc phyl rux Scer\FLP1 sev sev::tor slmb Sos spi tll tor ttk w
Insertions (1)
	P{lacW}ebi^k16213