Open Close
Reference
Citation
Dong, X., Tsuda, L., Zavitz, K.H., Lin, M., Li, S., Carthew, R.W., Zipursky, S.L. (1999). ebi regulates epidermal growth factor receptor signaling pathways in Drosophila.  Genes Dev. 13(8): 954--965.
FlyBase ID
FBrf0108171
Publication Type
Research paper
Abstract

ebi regulates the epidermal growth factor receptor (EGFR) signaling pathway at multiple steps in Drosophila development. Mutations in ebi and Egfr lead to similar phenotypes and show genetic interactions. However, ebi does not show genetic interactions with other RTKs (e.g., torso) or with components of the canonical Ras/MAP kinase pathway. ebi encodes an evolutionarily conserved protein with a unique amino terminus, distantly related to F-box sequences, and six tandemly arranged carboxy-terminal WD40 repeats. The existence of closely related proteins in yeast, plants, and humans suggests that ebi functions in a highly conserved biochemical pathway. Proteins with related structures regulate protein degradation. Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development.

PubMed ID
PubMed Central ID
PMC316643 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Aberrations (1)
    Alleles (21)
    Gene Groups (1)
    Genes (19)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (7)