Reference Report

Reference
Citation	Sato, M., Kojima, T., Michiue, T., Saigo, K. (1999). Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. Development 126(7): 1457--1466. (Export to RIS)
FlyBase ID	FBrf0108268
Publication Type	Research paper
PubMed ID	10068639
PubMed Abstract	In Drosophila notum, the expression of achaete-scute proneural genes and bristle formation have been shown to be regulated by putative prepattern genes expressed longitudinally. Here, we show that two homeobox genes at the Bar locus (BarH1 and BarH2) may belong to a different class of prepattern genes expressed latitudinally, and suggest that the developing notum consists of checker-square-like subdomains, each governed by a different combination of prepattern genes. BarH1 and BarH2 are coexpressed in the anterior-most notal region and regulate the formation of microchaetae within the region of BarH1/BarH2 expression through activating achaete-scute. Presutural macrochaetae formation also requires Bar homeobox gene activity. Bar homeobox gene expression is restricted dorsally and posteriorly by Decapentaplegic signaling, while the ventral limit of the expression domain of Bar homeobox genes is determined by wingless whose expression is under the control of Decapentaplegic signaling.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(1)B Df(1)BH2
Alleles (40)
	ac^Hw-49c ara¹ arm⁸ arm^{Δ.Scer\UAS.T:Ivir\HA1} B-H1^hs.PK B-H1^{Scer\FRT.Scer\UAS} B-H1^Scer\UAS.cSa B-H2^25B B-H2^hs.PH B-H2^P058 B-H2^S8 B-H2^Scer\UAS.cSa caup¹ dpp¹⁰⁶³⁸ dpp^d12 dpp^d14 dpp^Scer\UAS.cFa Ecol\lacZ^ara-rF209 Ecol\lacZ^B-H1.B4.5 Ecol\lacZ^B-H2-P058 Ecol\lacZ^neur-A101 Ecol\lacZ^{Scer\UAS.T:SV40\nls2} f^SH Fim^+tSa hh⁴ pnr^D1 pnr^V1 pnr^VX1 Rnor\CD2^{Scer\UAS.cDBa} Scer\GAL4^ap-md544 Scer\GAL4^arm.PS Scer\GAL4^{B-H1.B4.5.B-H2.S8} Scer\GAL4^B-H1.B4.5 Scer\GAL4^C-765 Scer\GAL4^pnr-MD237 tkv⁴ tkv^{Q253D.Scer\FRT.Scer\UAS} wg^17en40cP1 wg^l-12 wg^Sp-1
Constructs (16)
	P{B-H1-GAL4.B4.5} P{B-H1-lacZ.B4.5} P{B-H2.S8} P{BN-GAL4} P{Fim} P{GAL4-arm.S} P{hs-B-H1.K} P{hs-B-H2.H} P{UAS(FRT.y⁺CD2)tkv.Q253D.Nc} P{UAS-arm.Δ.flu} P{UAS-B-H1.FRT.S} P{UAS-B-H1.S} P{UAS-B-H2.S} P{UAS-CD2} P{UAS-dpp.BEH1} P{UAS-lacZ.NZ}
Genes (20)
	ac anon-X2 ara arm B-H1 B-H2 caup dpp Ecol\lacZ f Fim hh pnr Rnor\CD2 sc Scer\GAL4 T:Ivir\HA1 T:SV40\nls2 tkv wg
Insertions (6)
	P{GawB}ap^md544 P{GawB}C-765 P{GawB}pnr^MD237 P{lArB}B-H2^P058 P{lArB}neur^A101 P{PZ}ara^rF209