Reference Report

Reference
Citation	Soldatov, A., Nabirochkina, E., Georgieva, S., Belenkaja, T., Georgiev, P. (1999). TAFII40 protein is encoded by the e(y)1 gene: biological consequences of mutations. Mol. Cell. Biol. 19(5): 3769--3778. (Export to RIS)
FlyBase ID	FBrf0108279
Publication Type	Research paper
PubMed ID	10207100
PubMed Abstract	The enhancer of yellow 1 gene, e(y)1, of Drosophila melanogaster has been cloned and demonstrated to encode the TAFII40 protein. The e(y)1 gene is expressed in females much more strongly than in males due to the accumulation of e(y)1 mRNA in the ovaries. Two different e(y)1 mutations have been obtained. The e(y)1(ul) mutation, induced by the insertion of Stalker into the coding region, leads to the replacement of 25 carboxy-terminal amino acids by 17 amino acids encoded by the Stalker sequences and to a decrease of the e(y)1 transcription level. The latter is the main cause of dramatic underdevelopment of the ovaries and sterility of females bearing the e(y)1 mutation. This follows from the restoration of female fertility upon transformation of e(y)1(u1) flies with a construction synthesizing the mutant protein. The e(y)1(P1) mutation induced by P element insertion into the transcribed nontranslated region of the gene has almost no influence on the phenotype of flies. However, in combination with the phP1 mutation, which leads to a strong P element-mediated suppression of e(y)1 transcription, this mutation is lethal. Genetic studies of the e(y)1(u1) mutation revealed a sensitivity of the yellow and white expression to the TAFII40/e(y)1 level. The su(Hw)-binding region, Drosophila insulator, stabilizes the expression of the white gene and makes it independent of the e(y)1(u1) mutation.
DOI
Related Publication(s)
Review	Paper alert. Aasland, 1999, Curr. Opin. Genet. Dev. 9(4): 378 [FBrf0125317]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell. Biol.
Title	Molecular and Cellular Biology
Publication Year	1981-
ISBN/ISSN	0270-7306
Data from Reference
Alleles (19)
	e(y)1^1.tSa e(y)1¹ e(y)1^+tSa e(y)1^P1 e(y)3⁴ ph-p^P1 su(Hw)² su(Hw)^V w^+mC w^BR.E.BR w^E.BR y² y^2PR1 y^2PR2 y^76d28 y^+1MC y^+2MC y^+3MC z^v77h
Constructs (5)
	P{CaSpeR-3} P{e(y)1^1.tSa} P{e(y)1^+tSa} P{su(Hw)BR-w.2} P{SUPor-P}
Genes (7)
	e(y)1 e(y)3 ph-p su(Hw) w y z
Insertions (9)
	gypsy{?'}y^+1MC gypsy{?'}y^+3MC gypsy{}y² H{}y^2PR2 jockey{}y^2PR1 jockey{}y^+2MC P{}e(y)1^P1 P{}y^76d28 Stalker{}e(y)1¹