Reference Report

Reference
Citation	Wes, P.D., Xu, X.Z., Li, H.S., Chien, F., Doberstein, S.K., Montell, C. (1999). Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat. Neurosci. 2(5): 447--453. (Export to RIS)
FlyBase ID	FBrf0108298
Publication Type	Research paper
PubMed ID	10321249
PubMed Abstract	Many of the proteins that are critical for Drosophila phototransduction assemble into a signaling complex, signalplex, through association with the PDZ-domain protein INAD. Some of these proteins depend on INAD for proper subcellular localization to the phototransducing organelle, the rhabdomere, making it difficult to assess any physiological function of this signaling complex independent of localization. Here we demonstrated that INAD bound directly to the NINAC myosin III, yet the subcellular localization of NINAC was normal in inaD mutants. Nevertheless, the INAD binding site was sufficient to target a heterologous protein to the rhabdomeres. Disruption of the NINAC/INAD interaction delayed termination of the photoreceptor response. Thus one role of this signaling complex is in rapid deactivation of the photoresponse.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Alleles (10)
	inaD^T1 ninaC⁵ ninaC^{40C.T:Ecol\lacZ} ninaC^{40C-I1501E.T:Ecol\lacZ} ninaC^1015.4 ninaC^I1501E ninaC^KD ninaC^MD ninaC^ΔB y^+mDint2
Constructs (7)
	P{ninaC.I1501E} P{ninaC^1015.4} P{ninaC^KD} P{ninaC^MD} P{ninaC^ΔB} P{ninaC-lacZ.40C} P{ninaC-lacZ.40C-I1501E}
Genes (6)
	Gαq inaD ninaC T:Ecol\lacZ trp y
Natural transposons (1)
	P-element