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Citation
Delattre, M., Briand, S., Paces-Fessy, M., Blanchet-Tournier, M.F. (1999). The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals.  Dev. Genes Evol. 209(5): 294--300.
FlyBase ID
FBrf0108396
Publication Type
Research paper
Abstract
The Suppressor of fused [Su(fu)] gene of Drosophila melanogaster encodes a protein containing a PEST sequence [sequence enriched in proline (P), glutamic acid (E), serine (S) and threonine (T)] which acts as an antagonist to the serine-threonine kinase Fused in Hedgehog (Hh) signal transduction during embryogenesis. The Su(fu) gene isolated from a distantly related Drosophila species, D. virilis, shows significantly high homology throughout its protein sequence with its D. melanogaster counterpart. We show that these two Drosophila homologs of Su(fu) are functionally interchangeable in enhancing the fused phenotype. We have also isolated mammalian homologs of Su(fu). The absence of the PEST sequence in the mammalian Su(fu) protein suggests a different regulation for this product between fly and vertebrates. Using the yeast two-hybrid method, we show that the murine Su(fu) protein can interact directly with the Fused and Cubitus interruptus proteins, known partners of Su(fu) in Drosophila. These data are discussed in the light of their evolutionary relationships.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Genes Evol.
    Title
    Development genes and evolution
    Publication Year
    1996-
    ISBN/ISSN
    0949-944X
    Data From Reference
    Alleles (4)
    Genes (6)
    Transgenic Constructs (1)