Open Close
Reference
Citation
Van Etten, R.A. (1999). Cycling, stressed-out and nervous: cellular functions of c-Abl.  Trends Cell Biol. 9(5): 179--186.
FlyBase ID
FBrf0108476
Publication Type
Review
Abstract

c-Abl, the product of the cellular homologue of the transforming gene of Abelson murine leukaemia virus, has been a protein in search of a purpose for over two decades. Because c-Abl is implicated in the pathogenesis of several human leukaemias, understanding the functions of Abl is an important goal. Recently, biochemical and genetic approaches have converged to shed new light on the mechanism of regulation of c-Abl kinase activity and the multiple roles of c-Abl in cellular physiology. This review summarizes our current understanding of the many facets of c-Abl biology, emphasizing recent studies on Drosophila and mammalian Abl.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Trends Cell Biol.
    Title
    Trends in Cell Biology
    Publication Year
    1991-
    ISBN/ISSN
    0962-8924
    Data From Reference
    Genes (13)