Reference Report

Reference
Citation	Kramer, S., Okabe, M., Hacohen, N., Krasnow, M.A., Hiromi, Y. (1999). Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 126(11): 2515--2525. (Export to RIS)
FlyBase ID	FBrf0108521
Publication Type	Research paper
PubMed ID	10226010
PubMed Abstract	Extracellular factors such as FGF and EGF control various aspects of morphogenesis, patterning and cellular proliferation in both invertebrates and vertebrates. In most systems, it is primarily the distribution of these factors that controls the differential behavior of the responding cells. Here we describe the role of Sprouty in eye development. Sprouty is an extracellular protein that has been shown to antagonize FGF signaling during tracheal branching in Drosophila. It is a novel type of protein with a highly conserved cysteine-rich region. In addition to the embryonic tracheal system, sprouty is also expressed in other tissues including the developing eye imaginal disc, embryonic chordotonal organ precursors and the midline glia. In each of these tissues, EGF receptor signaling is known to participate in the control of the correct number of neurons or glia. We show that, in all three tissues, the loss of sprouty results in supernumerary neurons or glia, respectively. Furthermore, overexpression of sprouty in wing veins and ovarian follicle cells, two other tissues where EGF signaling is required for patterning, results in phenotypes that resemble the loss-of-function phenotypes of Egf receptor. These results suggest that Sprouty acts as an antagonist of EGF as well as FGF signaling pathways. These receptor tyrosine kinase-mediated pathways may share not only intracellular signaling components but also extracellular factors that modulate the strength of the signal.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (5)
	Df(3L)1226 Df(3L)A466 Df(3L)HR119 Df(3L)HR232 Df(3L)HR370
Alleles (31)
	aop^yan-1 aos²⁵⁷ aos^GMR.PS bnl⁰⁰⁸⁵⁷ btl^Δ10 Ecol\lacZ^AA142 Ecol\lacZ^klg-H214 Ecol\lacZ^P82 Ecol\lacZ^rho-X81 Ecol\lacZ^sty-09143 Ecol\lacZ^svp-AE127 htl⁸⁰ pnt¹ Ras85D^C33 Ras85D^e2F Ras85D^N17.hs.2sev RasGAP1^B2 Scer\GAL4^BH1 Scer\GAL4^CY2 Scer\GAL4^elav-C155 Scer\GAL4^en-e16E Scer\GAL4^hs.2sev sev¹⁴ sina² sty²²⁶ sty²⁵⁴ sty^F7 sty^G5 sty^Scer\UAS.cHa sty^unspecified sty^Δ5
Constructs (4)
	P{GAL4-Hsp70.sev} P{GMR-argos.S} P{sevhs-Ras1^N17} P{UAS-sty.H}
Genes (18)
	aop aos arm B-H1 B-H2 bnl btl Ecol\lacZ Egfr elav htl pnt Ras85D RasGAP1 Scer\GAL4 sev sina sty
Insertions (10)
	P{en2.4-GAL4}e16E P{GawB}BH1 P{GawB}CY2 P{GawB}elav^C155 P{HZ}klg^H214 P{lacZ-un1}P82 P{lwB}AA142 P{lwB}svp^AE127 P{lwB}X81 P{PZ}eIF5B⁰⁹¹⁴³