Reference Report

Reference
Citation	Bishop, S.A., Klein, T., Martinez Arias, A., Couso, J.P. (1999). Composite signalling from Serrate and establishes leg segments in Drosophila through Notch. Development 126(13): 2993--3003. (Export to RIS)
FlyBase ID	FBrf0108607
Publication Type	Research paper
PubMed ID	10357942
PubMed Abstract	The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activities. Coincident stripes of Serrate and Delta expressing cells activate Enhancer of split expression in adjacent cells through Notch signalling. These cells form a patterning boundary from which a putative secondary signal leads to the development of leg joints. Elsewhere in the tarsal segments, signalling by DELTA and NOTCH is necessary for the development of non-joint parts of the leg. We propose that these two effects result from different thresholds of NOTCH activation, which are translated into different downstream gene expression effects. We propose a general mechanism for creation of boundaries by Notch signalling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3R)D605
Alleles (20)
	Dl^6B Dl^RF Dl^Scer\UAS.cDa dsh¹ Ecol\lacZ^disco-rH219 Ecol\lacZ^Dl-A326.2F3 Ecol\lacZ^E(spl).2.61 Ecol\lacZ^fng-2B2 Ecol\lacZ^Scer\UAS.cUa fng^2B2 fng^Scer\UAS.cKa N^55e11 N^ECN.Scer\UAS N^{int.SH.Scer\UAS} N^l1N-ts1 Scer\GAL4^ap-md544 Scer\GAL4^Dll-md23 Scer\GAL4^klu-G410 Ser^RX106 Ser^Scer\UAS.cSa
Constructs (7)
	P{E(spl)-2.61} P{UAS-Dl.D} P{UAS-fng.K} P{UAS-lacZ.U} P{UAS-N.ECN} P{UAS-N.intra.SH} P{UAS-Ser.mg5603}
Genes (9)
	Dl dsh E(spl)mγ-HLH E(spl)mδ-HLH Ecol\lacZ fng N Scer\GAL4 Ser
Insertions (6)
	P{GAL4}klu^G410 P{GawB}ap^md544 P{GawB}Dll^md23 P{lacZ}fng^2B2 P{lArB}disco^rH219 P{lArB}Dl^A326.2F3