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Reference
Citation
Diez del Corral, R., Aroca, P., Gomez-Skarmeta, J.L., Cavodeassi, F., Modolell, J. (1999). The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.  Genes Dev. 13(13): 1754--1761.
FlyBase ID
FBrf0108698
Publication Type
Research paper
Abstract

The Iroquois complex (Iro-C) homeodomain proteins allow cells at the proximal part of the Drosophila imaginal wing disc to form mesothoracic body wall (notum). Cells lacking these proteins form wing hinge structures instead (tegula and axillary sclerites). Moreover, the mutant cells impose on neighboring wild-type cells more distal developmental fates, like lateral notum or wing hinge. These findings support a tergal phylogenetic origin for the most proximal part of the wing and provide evidence for a novel pattern organizing center at the border between the apposed notum (Iro-C-expressing) and hinge (Iro-C-nonexpressing) cells. This border is not a cell lineage restriction boundary.

PubMed ID
PubMed Central ID
PMC316847 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Aberrations (2)
    Alleles (7)
    Genes (10)
    Insertions (2)
    Transgenic Constructs (3)