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Citation
Matsumoto, A., Tomioka, K., Chiba, Y., Tanimura, T. (1999). timrit lengthens circadian period in a temperature-dependent manner through suppression of PERIOD protein cycling and nuclear localization.  Mol. Cell. Biol. 19(6): 4343--4354.
FlyBase ID
FBrf0108911
Publication Type
Research paper
Abstract

A fundamental feature of circadian clocks is temperature compensation of period. The free-running period of ritsu (timrit) (a novel allele of timeless [tim]) mutants is drastically lengthened in a temperature-dependent manner. PER and TIM protein levels become lower in timrit mutants as temperature becomes higher. This mutation reduces per mRNA but not tim mRNA abundance. PER constitutively driven by the rhodopsin1 promoter is lowered in rit mutants, indicating that timrit mainly affects the per feedback loop at a posttranscriptional level. An excess of per+ gene dosage can ameliorate all rit phenotypes, including the weak nuclear localization of PER, suggesting that timrit affects circadian rhythms by reducing PER abundance and its subsequent transportation into nuclei as temperature increases.

PubMed ID
PubMed Central ID
PMC104394 (PMC) (EuropePMC)
DOI
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cell. Biol.
    Title
    Molecular and Cellular Biology
    Publication Year
    1981-
    ISBN/ISSN
    0270-7306
    Data From Reference
    Aberrations (4)
    Alleles (6)
    Genes (2)
    Transgenic Constructs (2)