Reference Report

Reference
Citation	Su, M.T., Fujioka, M., Goto, T., Bodmer, R. (1999). The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision. Development 126(14): 3241--3251. (Export to RIS)
FlyBase ID	FBrf0109098
Publication Type	Research paper
PubMed ID	10375513
PubMed Abstract	A series of inductive signals are necessary to subdivide the mesoderm in order to allow the formation of the progenitor cells of the heart. Mesoderm-endogenous transcription factors, such as those encoded by twist and tinman, seem to cooperate with these signals to confer correct context and competence for a cardiac cell fate. Additional factors are likely to be required for the appropriate specification of individual cell types within the forming heart. Similar to tinman, the zinc finger- and homeobox-containing gene, zfh-1, is expressed in the early mesoderm and later in the forming heart, suggesting a possible role in heart development. Here, we show that zfh-1 is specifically required for formation of the even-skipped (eve)-expressing subset of pericardial cells (EPCs), without affecting the formation of their siblings, the founders of a dorsal body wall muscle (DA1). In addition to zfh-1, mesodermal eve itself appears to be needed for correct EPC differentiation, possibly as a direct target of zfh-1. Epistasis experiments show that zfh-1 specifies EPC development independently of numb, the lineage gene that controls DA1 founder versus EPC cell fate. We discuss the combinatorial control mechanisms that specify the EPC cell fate in a spatially precise pattern within the embryo.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2R)520 Df(3R)ZZ27
Alleles (12)
	Ecol\lacZ^eve.C3DZ.enh Ecol\lacZ^eve.C3DZ eve¹ eve^Scer\UAS.cBa numb² numb^{fl.Scer\UAS.T:Hsap\MYC} Scer\GAL4^how-24B Scer\GAL4^twi.PG spi¹ stg² w^+mC zfh1²
Constructs (4)
	P{eve-lacZ.C3DZ.enh} P{GAL4-twi.G} P{UAS-eve.B} P{UAS-numb.T:Myc.Y}
Genes (11)
	Ecol\lacZ eve Mef2 numb Scer\GAL4 spdo spi stg T:Hsap\MYC w zfh1
Insertions (1)
	P{GawB}how^24B
Transcripts (1)
	Ecol\lacZ^eve.C3DZRA