Reference Report

Reference
Citation	Agudo, M., Losada, A., Abad, J.P., Pimpinelli, S., Ripoll, P., Villasante, A. (1999). Centromeres from telomeres? The centromeric region of the Y chromosome of Drosophila melanogaster contains a tandem array of telomeric HeT-A- and TART-related sequences. Nucleic Acids Res. 27(16): 3318--3324. (Export to RIS)
FlyBase ID	FBrf0109216
Publication Type	Research paper
PubMed ID	10454639
PubMed Abstract	Cytological and cytogenetic studies have previously defined the region needed for centromeric function in the Y chromosome of Drosophila melanogaster. We have identified a YAC clone that originated from this region. Molecular analysis of the YAC and genomic DNAs has allowed the description of a satellite DNA made of telomeric HeT-A- and TART-derived sequences and the construction of a long-range physical map of the heterochromatic region h18. Sequences within the YAC clone are conserved in the centromeric region of the sibling species Drosophila simulans. That telomere-derived DNA now forms part of the centromeric region of the Y chromosome could indicate a telomeric origin of this centromere. The existence of common determinants for the function of both centromeres and telomeres is discussed.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Nucleic Acids Res.
Title	Nucleic Acids Research
Publication Year	1974-
ISBN/ISSN	0305-1048
Data from Reference
Aberrations (3)
	T(Y;2)A77 T(Y;2)A77p Ts(YLt;2Lt)A77
Genes (2)
	Dsim\dodeca satDNA
Natural transposons (5)
	Circe copia F-element HeT-A TART-element