Reference Report

Reference
Citation	Payre, F., Vincent, A., Carreno, S. (1999). ovo/svb integrates Wingless and DER pathways to control epidermis differentiation. Nature 400(6741): 271--275. (Export to RIS)
FlyBase ID	FBrf0110515
Publication Type	Research paper
PubMed ID	10421370
PubMed Abstract	In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female germline development and svb for epidermal morphogenesis. In the Drosophila embryo, the ventral epidermis consists of the segmental alternance of two major cell types that produce either naked cuticle or cytoplasmic extrusions known as denticles. Wingless signalling specifies smooth cells that produce naked cuticle, whereas the activation of the Drosophila epidermal growth factor (EGF) receptor (DER) leads to the production of denticles. Here we show that expression of the ovo/svb gene controls the choice between these cell fates. We find that svb is a key selector gene that, cell autonomously, directs cytoskeletal modifications producing the denticle. The DER pathway promotes denticle formation by activating svb expression. Conversely, Wingless promotes the smooth cell fate through the transcriptional repression of svb by the bipartite nuclear factor Armadillo/dTcf. Our data indicate that transcriptional regulation of svb integrates inputs from the Wingless and DER pathways and controls epidermal differentiation.
DOI
Related Publication(s)
Review	Paper alert. Kodjabachian, 1999, Curr. Opin. Genet. Dev. 9(5): 493 [FBrf0125373]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (18)
	arm^{S10.Scer\UAS.T:Hsap\MYC} Ecol\lacZ^Scer\UAS.cUa Egfr^DN.Scer\UAS ovo^D1.Scer\UAS ovo^Scer\UAS.cPa ovo^svb-1 ovo^svb-2 pan^ΔN.Scer\UAS Ras85D^V12.Scer\UAS Scer\GAL4^69B Scer\GAL4^e22c Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL4^unspecified Scer\GAL4^wg.PM spi^s.Scer\UAS w^+mC wg^l-17
Constructs (9)
	P{GAL4-wg.M} P{UAS-arm.S10} P{UAS-Egfr.DN} P{UAS-lacZ.U} P{UAS-ovo.D1} P{UAS-ovo.P} P{UAS-pan.dTCFΔN} P{UAS-Ras85D.V12} P{UAS-spi.s}
Genes (12)
	arm Ecol\lacZ Egfr ovo pan Ras85D rl Scer\GAL4 spi T:Hsap\MYC w wg
Insertions (4)
	P{en2.4-GAL4}e16E P{en2.4-GAL4}e22c P{GawB}69B P{GawB}ptc^559.1