|Citation||Qureshi, S.T., Gros, P., Malo, D. (1999). Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes. Trends Genet. 15(8): 291--294. (Export to RIS)|
|PubMed Abstract||Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.|
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|Language of Publication||English|
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|Title||Trends in Genetics|
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