Open Close
Reference
Citation
Sanson, B., Alexandre, C., Fascetti, N., Vincent, J.P. (1999). Engrailed and hedgehog make the range of Wingless asymmetric in Drosophila embryos.  Cell 98(2): 207--216.
FlyBase ID
FBrf0110710
Publication Type
Research paper
Abstract

In many instances, remote signaling involves the transport of secreted molecules. Here, we examine the spread of Wingless within the embryonic epidermis of Drosophila. Using two assays for Wingless activity (specification of naked cuticle and repression of rhomboid transcription), we found that Wingless acts at a different range in the anterior and posterior directions. We show that this asymmetry follows in part from differential distribution of the Wingless protein. Transport or stability is reduced within engrailed-expressing cells, and farther posteriorward Wingless movement is blocked at the presumptive segment boundary and perhaps beyond. We demonstrate the role of hedgehog in the formation of this barrier.

PubMed ID
PubMed Central ID
Related Publication(s)
Review

Paper alert.
Jones, 1999, Curr. Opin. Genet. Dev. 9(5): 491 [FBrf0125369]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference