Reference Report

Reference
Citation	Shao, Z., Raible, F., Mollaaghababa, R., Guyon, J.R., Wu, C.T., Bender, W., Kingston, R.E. (1999). Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 98(1): 37--46. (Export to RIS)
FlyBase ID	FBrf0110782
Publication Type	Research paper
PubMed ID	10412979
PubMed Abstract	The Polycomb group (PcG) genes are required for maintenance of homeotic gene repression during development. Mutations in these genes can be suppressed by mutations in genes of the SWI/SNF family. We have purified a complex, termed PRC1 (Polycomb repressive complex 1), that contains the products of the PcG genes Polycomb, Posterior sex combs, polyhomeotic, Sex combs on midleg, and several other proteins. Preincubation of PRC1 with nucleosomal arrays blocked the ability of these arrays to be remodeled by SWI/SNF. Addition of PRC1 to arrays at the same time as SWI/SNF did not block remodeling. Thus, PRC1 and SWI/SNF might compete with each other for the nucleosomal template. Several different types of repressive complexes, including deacetylases, interact with histone tails. In contrast, PRC1 was active on nucleosomal arrays formed with tailless histones.
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Review	Paper alert. Jones, 1999, Curr. Opin. Genet. Dev. 9(5): 491--492 [FBrf0125371]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (6)
	ph-d⁵⁰⁵ ph-p⁵⁰⁵ ph-p^T:Zzzz\FLAG Psc^e24 Psc^h27 Psc^T:Zzzz\FLAG
Constructs (2)
	P{Pc-ph-p.FLAG} P{Pc-Psc.FLAG}
Genes (8)
	brm mor Pc ph-d ph-p Psc Scm T:Zzzz\FLAG