Reference Report

Reference
Citation	Zorin, I.D., Gerasimova, T.I., Corces, V.G. (1999). The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila. Genetics 152(3): 1045--1055. (Export to RIS)
FlyBase ID	FBrf0111197
Publication Type	Research paper
External Crossreferences
PubMed ID	10388823
PubMed Abstract	Mutations in the lawc gene result in a pleiotropic phenotype that includes homeotic transformation of the arista into leg. lawc mutations enhance the phenotype of trx-G mutations and suppress the phenotype of Pc mutations. Mutations in lawc affect homeotic gene transcription, causing ectopic expression of Antennapedia in the eye-antenna imaginal disc. These results suggest that lawc is a new member of the trithorax family. The lawc gene behaves as an enhancer of position-effect variegation and interacts genetically with mod(mdg4), which is a component of the gypsy insulator. In addition, mutations in the lawc gene cause alterations in the punctated distribution of mod(mdg4) protein within the nucleus. These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin.
BIOSIS ID	1999.377846
Zoological Record ID
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Secondary IDs
Language of Publication	English
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ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Editors
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (4)
	Df(1)KA14 Df(1)RA2 Df(3L)Pc-MK In(1)w^m4
Alleles (13)
	ash1¹⁷ bi^D11 brm² bw^D lawc⁺¹⁰ lawc^EF520 lawc^p1 mod(mdg4)^ul Pc⁴ trx^B11 trx^E2 y² y^v2
Genes (14)
	Antp ash1 bi brm bw lab lawc mod(mdg4) Pc Scr trx Ubx w y
Insertions (1)
	gypsy{}y²