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Citation
Johnston, L.A., Prober, D.A., Edgar, B.A., Eisenman, R.N., Gallant, P. (1999). Drosophila myc regulates cellular growth during development.  Cell 98(6): 779--790.
FlyBase ID
FBrf0111393
Publication Type
Research paper
Abstract

Transcription factors of the Myc proto-oncogene family promote cell division, but how they do this is poorly understood. Here we address the functions of Drosophila Myc (dMyc) during development. Using mosaic analysis in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc overproduction increases growth rates and cell size. dMyc-induced growth promotes G1/S progression but fails to accelerate cell division because G2/M progression is independently controlled by Cdc25/String. We also show that the secreted signal Wingless patterns growth in the wing primordium by modulating dMyc expression. Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism.

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Related Publication(s)
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Paper alert.
Ridley, 1999, Curr. Opin. Genet. Dev. 9(6): 610 [FBrf0125399]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference