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Citation
Kelley, R.L., Meller, V.H., Gordadze, P.R., Roman, G., Davis, R.L., Kuroda, M.I. (1999). Epigenetic spreading of the Drosophila dosage compensation complex from roX RNA genes into flanking chromatin.  Cell 98(4): 513--522.
FlyBase ID
FBrf0111396
Publication Type
Research paper
Abstract

The multisubunit MSL dosage compensation complex binds to hundreds of sites along the Drosophila single male X chromosome, mediating its hypertranscription. The male X chromosome is also coated with noncoding roX RNAs. When either msl3, mle, or mof is mutant, a partial MSL complex is bound at only approximately 35 unusual sites distributed along the X. We show that two of these sites are the roX1 and roX2 genes and postulate that one of their functions is to provide entry sites for the MSL complex to recognize the X chromosome. The roX1 gene provides a nucleation site for extensive spreading of the MSL complex into flanking chromatin even when moved to an autosome. The spreading can occur in cis or in trans between paired homologs. We present a model for how the dosage compensation complex recognizes X chromatin.

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Review

Paper alert.
Aasland, 1999, Curr. Opin. Genet. Dev. 9(6): 612 [FBrf0125403]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference