Reference Report

Reference
Citation	Madden, K., Crowner, D., Giniger, E. (1999). lola has the properties of a master regulator of axon-target interaction for SNb motor axons of Drosophila. Dev. Biol. 213(2): 301--313. (Export to RIS)
FlyBase ID	FBrf0111420
Publication Type	Research paper
PubMed ID	10479449
PubMed Abstract	The proper pathfinding and target recognition of an axon requires the precisely choreographed expression of a multitude of guidance factors: instructive and permissive, positive and negative, and secreted and membrane bound. We show here that the transcription factor LOLA is required for pathfinding and targeting of the SNb motor nerve in Drosophila. We also show that lola is a dose-dependent regulator of SNb development: by varying the expression of one lola isoform we can progressively titrate the extent of interaction of SNb motor axons with their target muscles, from no interaction at all, through wild-type patterning, to apparent hyperinnervation. The phenotypes we observe from altered expression of LOLA suggest that this protein may help orchestrate the coordinated expression of the genes required for faithful SNb development.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	In(2LR)O
Alleles (13)
	Ecol\lacZ^Act5C.PB lola^1A4 lola^3.8.Scer\UAS lola^4.7.Scer\UAS lola^5D2 lola^c46 lola^e76 lola^g9 lola^unspecified Scer\GAL4^elav.PLu Scer\GAL4^how-24B Scer\GAL4^twi.PBa w^+mC
Balancers (1)
	CyO-β-actin
Constructs (5)
	P{act-lacZ.B} P{GAL4-elav.L} P{GAL4-twi.BS} P{UAS-lola.3.8} P{UAS-lola.4.7}
Genes (12)
	Ecol\lacZ eve Fas2 Fas3 futsch lola Mhc Scer\GAL4 slou Syt1 Tl w
Insertions (3)
	P{GawB}how^24B P{lacW}lola^1A4 P{lacW}lola^5D2