Reference Report

Reference
Citation	Paricio, N., Feiguin, F., Boutros, M., Eaton, S., Mlodzik, M. (1999). The Drosophila STE20-like kinase misshapen is required downstream of the frizzled receptor in planar polarity signaling. EMBO J. 18(17): 4669--4678. (Export to RIS)
FlyBase ID	FBrf0111453
Publication Type	Research paper
PubMed ID	10469646
PubMed Abstract	The Drosophila misshapen (msn) gene is a member of the STE20 kinase family. We show that msn acts in the Frizzled (Fz) mediated epithelial planar polarity (EPP) signaling pathway in eyes and wings. Both msn loss- and gain-of-function result in defective ommatidial polarity and wing hair formation. Genetic and biochemical analyses indicate that msn acts downstream of fz and dishevelled (dsh) in the planar polarity pathway, and thus implicates an STE20-like kinase in Fz/Dsh-mediated signaling. This demonstrates that seven-pass transmembrane receptors can signal via members of the STE20 kinase family in higher eukaryotes. We also show that Msn acts in EPP signaling through the JNK (Jun-N-terminal kinase) module as it does in dorsal closure. Although at the level of Fz/Dsh there is no apparent redundancy in this pathway, the downstream effector JNK/MAPK (mitogen-activated protein kinase) module is redundant in planar polarity generation. To address the nature of this redundancy, we provide evidence for an involvement of the related MAP kinases of the p38 subfamily in planar polarity signaling downstream of Msn.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Aberrations (9)
	Df(1)G24 Df(1)H6 Df(2L)b80e3 Df(2L)b87e25 Df(2L)flp170B Df(3L)Ar14-8 Df(3R)crb87-4 Df(3R)crb-F89-4 Df(3R)p13
Alleles (14)
	bsk² dock³ dsh¹ dsh^hs.sev.B hep^r75 Jra^IA109 msn¹⁰² msn¹⁷² msn^EP549 msn^Scer\UAS.cSa msn^unspecified Rho1^72O Scer\GAL4^ap-md544 Scer\GAL4^hs.2sev
Constructs (3)
	P{GAL4-Hsp70.sev} P{sE-Dsh.B} P{UAS-msn.S}
Genes (13)
	bsk dock dsh hep Jra lic Mkk4 Mpk2 msn p38b Rho1 salm Scer\GAL4
Insertions (2)
	P{EP}msn^EP549 P{GawB}ap^md544