Reference Report

Reference
Citation	Purcell, K., Artavanis-Tsakonas, S. (1999). The developmental role of warthog, the Notch modifier encoding Drab6. J. Cell Biol. 146(4): 731--740. (Export to RIS)
FlyBase ID	FBrf0111465
Publication Type	Research paper
PubMed ID	10459009
PubMed Abstract	The warthog (wrt) gene, recovered as a modifier for Notch signaling, was found to encode the Drosophila homologue of rab6, Drab6. Vertebrate and yeast homologues of this protein have been shown to regulate Golgi network to TGN trafficking. To study the function of this protein in the development of a multicellular organism, we analyzed three different warthog mutants. The first was an R62C point mutation, the second a genomic null, and the third was an engineered GTP-bound form. Our studies show, contrary to yeast, that the Drosophila homologue of rab6 is an essential gene. However, it has limited effects on development beyond the larval stage. Only the mechanosensory bristles on the head, notum, and scutellum are affected by warthog mutations. We present models for the modifying effect of Drab6 on Notch signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Cell Biol.
Title	Journal of Cell Biology
Publication Year	1966-
ISBN/ISSN	0021-9525
Data from Reference
Alleles (62)
	N^nucl.sev Phae1^tmed Phae1^tSacII:RI Phae1^tX:X5 Phae2^tmed Phae2^tSacII:RI Rab6⁰⁸³²³ Rab6^+t9-6 Rab6^+tmed Rab6^BN7 Rab6^BU1 Rab6^D1A Rab6^D1B Rab6^D2B Rab6^D2D Rab6^D3A Rab6^D4A Rab6^D5A Rab6^D5C Rab6^D6B Rab6^D6C Rab6^D6E Rab6^D7C Rab6^D9A Rab6^D9C Rab6^D9D Rab6^D10A Rab6^D11A Rab6^D12C Rab6^D13E Rab6^D14E Rab6^D15A Rab6^D17B Rab6^D17E Rab6^D22A Rab6^D23A Rab6^D23D Rab6^D23E Rab6^D24A Rab6^D27A Rab6^D28B Rab6^D28E Rab6^D29D Rab6^D30D Rab6^D31B Rab6^D35A Rab6^D37A Rab6^D39B Rab6^D39C Rab6^D40B Rab6^D40C Rab6^eAM4 Rab6^eAS1 Rab6^eER1 Rab6^hs.PP Rab6^MEF Rab6^Q71L.hs Rab6^R62C.hs Rab6^tSacII:RI Rab6^tX:X5 Rab6^unspecified w^+mC
Constructs (8)
	P{hs-Rab6.P} P{hs-Rab6.Q71L} P{hs-Rab6.R62C} P{Rab6^+t9-6} P{Rab6^+tmed} P{Rab6^tSacII:RI} P{Rab6^tX:X5} P{sev-Notch^nucl}
Genes (7)
	Aats-thr N Patsas Phae1 Phae2 Rab6 w
Insertions (9)
	?{}Rab6^D6E ?{}Rab6^D24A ?{}Rab6^D29D P{3'PZ}Rab6^D17B P{3'PZ}Rab6^D39C P{3'PZ}Rab6^D40B P{5'PZ}Rab6^D12C P{5'PZ}Rab6^D23E P{PZ}Rab6⁰⁸³²³