Reference Report

Reference
Citation	Willert, K., Logan, C.Y., Arora, A., Fish, M., Nusse, R. (1999). A Drosophila axin homolog, daxin, inhibits wnt signaling. Development 126(18): 4165--4173. (Export to RIS)
FlyBase ID	FBrf0111519
Publication Type	Research paper
PubMed ID	10457025
PubMed Abstract	The vertebrate Axin protein, the product of the mouse fused gene, binds to beta-catenin to inhibit Wnt signaling. We have identified a homolog of Axin in Drosophila, Daxin. Using double-stranded RNA interference, we generated loss-of-function phenotypes that are similar to overexpression of the Drosophila Wnt gene wingless (wg). Overexpression of Daxin produces phenotypes similar to loss of wg. In addition, we show that Daxin overexpression can modify phenotypes elicited by wg and another Drosophila Wnt gene, DWnt-2. Using immunoprecipitation of endogenous Daxin protein from embryos we show that Daxin interacts with Armadillo and Zeste-white 3. The loss-of-function and overexpression phenotypes show that Daxin, like its mammalian counterpart, acts as a negative regulator of wg/Wnt signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (16)
	Axn^{A1.Scer\UAS.T:Hsap\MYC} Axn^A1.Scer\UAS Axn^A1 Axn^A2.hs Axn^A2.Scer\UAS Axn^a.A1 Axn^{ΔRGS.Scer\UAS} pan^ΔN.Scer\UAS Scer\GAL4^69B Scer\GAL4^Act5C.PP Scer\GAL4^da.G32 Scer\GAL4^GMR.PF w^+mC wg^l-17 wg^Scer\UAS.cKa Wnt2^Scer\UAS.cKa
Constructs (10)
	P{GAL4-Act5C(-FRT).P} P{GAL4-da.G32} P{GAL4-ninaE.GMR} P{UAS-Axn.A1} P{UAS-Axn.A2} P{UAS-Axn.Myc} P{UAS-Axn.ΔRGS} P{UAS-pan.dTCFΔN} P{UAS-wg.K} P{UAS-Wnt2.K}
Genes (9)
	arm Axn pan Scer\GAL4 sgg T:Hsap\MYC w wg Wnt2
Insertions (1)
	P{GawB}69B