Reference Report

Reference
Citation	Zhang, Y.Q., Roote, J., Brogna, S., Davis, A.W., Barbash, D.A., Nash, D., Ashburner, M. (1999). stress sensitive B encodes an Adenine Nucleotide Translocase in Drosophila melanogaster. Genetics 153(2): 891--903. (Export to RIS)
FlyBase ID	FBrf0111529
Publication Type	Research paper
PubMed ID	10511565
PubMed Abstract	Adenine nucleotide translocases (ANT) are required for the exchange of ADP and ATP across the inner mitochondrial membrane. They are essential for life, and most eukaryotes have at least two different Ant genes. Only one gene had been described from Drosophila, and this had not been characterized genetically. We show that mutations in this gene correspond to the previously described loci, sesB and l(1)9Ed. Immediately adjacent to this gene is another encoding a second ANT protein, which has 78% identity to that encoded by sesB/l(1)9Ed. These two genes are transcribed from a common promoter, and their mRNAs are produced by differential splicing. Hutter and Karch suggested that the sesB ANT gene corresponded to Hmr, a gene identified by an allele that rescues otherwise inviable interspecific hybrids between Drosophila melanogaster and its sibling species. This hypothesis is not supported by our study of the ANT genes of D. melanogaster.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (21)
	Df(1)B13 Df(1)CH6 Df(1)HC133 Df(1)N110 Df(1)ras59 Df(1)ras203 Df(1)ras-TM5 Df(1)ras-TM6 Df(1)RJ7 Df(1)v64f Df(1)v-L3 Df(1)v-N48 Dp(1;2)v⁺63i Dp(1;2)v⁺75d Dp(1;3)v⁺74c Dp(1;Y)v⁺y⁺ In(1)AB In(1)AB^LAC2^R In(1)AC2 In(1)AC2^LAB^R T(1;2)ras-TM3
Alleles (21)
	Ant2^t10.3 Ant2^v64f Hmr¹ Hmr² l(1)9Ec¹ l(1)9Ec² l(1)9Ec³ l(1)9Ee¹ ras^l17 ras^l19 sesB¹ sesB³ sesB⁶ sesB^9Ed-1 sesB^9Ed-2 sesB^9Ed-3 sesB^9Ed-4 sesB^9Ed-5 sesB^9Ed-6 sesB^+t10.3 w^+mC
Constructs (1)
	P{Ant2⁺sesB⁺10.3}
Genes (12)
	Ant2 fliK Hmr l(1)9Ec l(1)9Ee l(1)9Fk l(1)9Fl ras sbr sesB v w
Insertions (4)
	P{Ant2⁺sesB⁺10.3}42A P{Ant2⁺sesB⁺10.3}102E P{HBDelta-23}9E P{HBΔ-23}sesB⁶