Reference Report

Reference
Citation	van Meyel, D.J., O'Keefe, D.D., Jurata, L.W., Thor, S., Gill, G.N., Thomas, J.B. (1999). Chip and apterous physically interact to form a functional complex during Drosophila development. Mol. Cell 4(2): 259--265. (Export to RIS)
FlyBase ID	FBrf0111533
Publication Type	Research paper
PubMed ID	10488341
PubMed Abstract	LIM homeodomain (LIM-HD) proteins play key roles in a variety of developmental processes throughout the animal kingdom. Here we show that the LIM-binding protein Chip acts as a cofactor for the Drosophila LIM-HD family member Apterous (Ap) in wing development. We define the domains of Chip required for LIM-HD binding and for homodimerization and show that mutant proteins deleted for these domains act in a dominant-negative fashion to disrupt Ap function. Our results support a model for multimeric complexes containing Chip and Ap in transcriptional regulation. This model is confirmed by the activity of a chimeric fusion between Chip and Ap that reconstitutes the complex and rescues the ap mutant phenotype.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Alleles (9)
	ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC} ap^md544 ap^P44 ap^Scer\UAS.cOa ap^{ΔLIM.Scer\UAS} Chi^{FL.Scer\UAS.T:Hsap\MYC} Chi^{ΔDD.Scer\UAS.T:Hsap\MYC} Chi^{ΔLID.Scer\UAS.T:Hsap\MYC} Scer\GAL4^ap-md544
Constructs (6)
	P{UAS-ap.O} P{UAS-ap.ΔLIM} P{UAS-Chi.FL} P{UAS-Chi.ΔDD} P{UAS-Chi.ΔLID} P{UAS-ChiΔLID::apΔLIM}
Genes (7)
	ap ap::Chi Chi Lim3 Scer\GAL4 T:Hsap\MYC tup
Insertions (1)
	P{GawB}ap^md544