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Chae, J., Kim, M.J., Goo, J.H., Collier, S., Gubb, D., Charlton, J., Adler, P.N., Park, W.J. (1999). The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family.  Development 126(23): 5421--5429.
FlyBase ID
FBrf0111831
Publication Type
Research paper
Abstract

The tissue polarity genes control the polarity of hairs, bristles and ommatidia in the adult epidermis of Drosophila. We report here the identification of a new tissue polarity gene named starry night (stan). Mutations in this essential gene alter the polarity of cuticular structures in all regions of the adult body. The detailed polarity phenotype of stan on the wing suggested that it is most likely a component of the frizzled (fz) pathway. Consistent with this hypothesis, stan appears to be downstream of and required for fz function. We molecularly cloned stan and found that it encodes a huge protocadherin containing nine cadherin motifs, four EGF-like motifs, two laminin G motifs, and seven transmembrane domains. This suggests that Stan functions in signal reception, perhaps together with Fz.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (10)
    Alleles (9)
    Genes (4)
    Transgenic Constructs (1)