Reference Report

Reference
Citation	Gao, F.B., Brenman, J.E., Jan, L.Y., Jan, Y.N. (1999). Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev. 13(19): 2549--2561.
FlyBase ID	FBrf0111874
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	10521399
PubMed Abstract	Signaling between neurons requires highly specialized subcellular structures, including dendrites and axons. Dendrites exhibit diverse morphologies yet little is known about the mechanisms controlling dendrite formation in vivo. We have developed methods to visualize the stereotyped dendritic morphogenesis in living Drosophila embryos. Dendrite development is altered in prospero mutants and in transgenic embryos expressing a constitutively active form of the small GTPase cdc42. From a genetic screen, we have identified several genes that control different aspects of dendrite development including dendritic outgrowth, branching, and routing. These genes include kakapo, a large cytoskeletal protein related to plectin and dystrophin; flamingo, a seven-transmembrane protein containing cadherin-like repeats; enabled, a substrate of the tyrosine kinase Abl; and nine potentially novel loci. These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis.
Biosis	2000.430229
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Erratum	Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Gao et al., 1999, Genes Dev. 13(23): 3170 [FBrf0125044]
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Secondary IDs
Language of publication	English
Additional language(s) of abstract
ISBN
Place of publication
Published In
Abbreviation	Genes Dev.
Title	Genes & Development
Authors
Volume range	1-
Year range	1987-
Page range
Publisher
Place of publication	Cold Spring Harbor, NY
Language of publication	English
ISBN/ISSN	0890-9369
CODEN	GEDEEP
Data from Reference
Aberrations (1)
	In(2LR)O
Alleles (46)
	Avic\GFP^{S65T.Scer\UAS} Avic\GFP^{Scer\UAS.T:Btau\MAPT} Cdc42^V12.Scer\UAS Rac1^V12.Scer\UAS Scer\GAL4^109(2)80 Scer\GAL4⁶⁰ Scer\GAL4^Kr.PM Scer\GAL4^elav.PLu Sema-1a^unspecified bnl^unspecified cypress⁴² ena⁰²⁰²⁹ ena²¹⁰ ena²³ ena⁴⁶ ena^GC5 ena^GC8 limber³⁵ ponderosa³³ pros¹⁷ pros^JO13 robo^unspecified saguaro⁵⁰ seq²² shot¹ shot² shot³⁰ shot^k03010 shot^k04204 shot^k05434b shot^k05821 shot^k10821 shot^k15606 shot^unspecified shrb⁴ shrv¹³ sli^unspecified stan⁷² stan^E45 stan^E59 stan^unspecified sty^unspecified tum¹⁴ tum^unspecified yew²¹ yew⁴¹
Balancers (1)
	CyO-19
Constructs (6)
	P{GAL4-Kr.C} P{GAL4-elav.L} P{UAS-Cdc42.V12} P{UAS-GFP.S65T} P{UAS-GFP.btau} P{UAS-Rac1.V12}
Genes (28)
	Avic\GFP Btau\MAPT Cdc42 Mef2 Rac1 Scer\GAL4 Sema-1a T:Btau\MAPT bnl cypress elav ena futsch limber numb ponderosa pros robo saguaro seq shot shrb shrv sli stan sty tum yew
Insertions (8)
	P{GAL4-Kr.C}DC3 P{GawB}109(2)80 P{GawB}60 P{PZ}ena⁰²⁰²⁹ P{UAS-GFP.S65T}DC7 P{lacW}shot^k04204 P{lacW}shot^k05434b P{lacW}shot^k10821