Open Close
Reference
Citation
Jarecki, J., Johnson, E., Krasnow, M.A. (1999). Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF.  Cell 99(2): 211--220.
FlyBase ID
FBrf0111925
Publication Type
Research paper
Abstract

The Drosophila tracheal (respiratory) system is a tubular epithelial network that delivers oxygen to internal tissues. Sprouting of the major tracheal branches is stereotyped and controlled by hard-wired developmental cues. Here we show that ramification of the fine terminal branches is variable and regulated by oxygen, and that this process is controlled by a local signal or signals produced by oxygen-starved cells. We provide evidence that the critical signal is Branchless (Bnl) FGF, the same growth factor that patterns the major branches during embryogenesis. During larval life, oxygen deprivation stimulates expression of Bnl, and the secreted growth factor functions as a chemoattractant that guides new terminal branches to the expressing cells. Thus, a single growth factor is reiteratively used to pattern each level of airway branching, and the change in branch patterning results from a switch from developmental to physiological control of its expression.

PubMed ID
PubMed Central ID
Related Publication(s)
Review

Paper alert.
Schuldt, 2000, Curr. Opin. Genet. Dev. 10(1): 7 [FBrf0125434]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference