Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Swan, A., Nguyen, T., Suter, B. (1999). Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nat. Cell Biol. 1(7): 444--449. (Export to RIS) | ||
| FlyBase ID | FBrf0112050 | ||
| Publication Type | Research paper | ||
| External Crossreferences | |||
| PubMed ID | 10559989 | ||
| PubMed Abstract | Here we show that the Drosophila homologue of Lissencephaly-1, DLis-1, acts together with Bicaudal-D (Bic-D), Egalitarian (Egl), dynein and microtubules to determine oocyte identity. DLis-1 is further required for nurse-cell-to-oocyte transport during oocyte growth, and for the positioning of the nucleus in the oocyte. Immunostaining of DLis-1 protein reveals a cortical localization that is independent of microtubules. DLis-1 may function in this position as a cortical anchor for the other nuclear-localization factors. DLis-1 and Bic-D are further required for nuclear localization in the developing nervous system, indicating that homologues of Bic-D, dynein and Egl-like proteins may also be involved in vertebrate neural migration and that their absence may cause a Miller-Dieker-like lissencephaly. | ||
| BIOSIS ID | |||
| Zoological Record ID | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2012_01 | |||
| FB2011_10 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Text of Personal Communication | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| ISBN | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Nat. Cell Biol. | ||
| Title | Nature Cell Biology | ||
| Editors | |||
| Publication Year | 1999- | ||
| ISBN/ISSN | 1465-7392 1476-4679 | ||
|
Data from Reference
|
|||
| Aberrations (2)
|
|||
| Alleles (7)
|
|||
| Genes (18)
|
|||
| Insertions (2)
|
|||