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Reference Report
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| Citation | Yu, X., Waltzer, L., Bienz, M. (1999). A new Drosophila APC homologue associated with adhesive zones of epithelial cells. Nat. Cell Biol. 1(3): 144--151. (Export to RIS) | ||
| FlyBase ID | FBrf0112095 | ||
| Publication Type | Research paper | ||
| PubMed ID | 10559900 | ||
| PubMed Abstract | Adenomatous polyposis coli protein (APC) is an important tumour suppressor in the human colon epithelium. In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin. Here, using a yeast two-hybrid screen for proteins that bind to the Drosophila beta-catenin homologue, Armadillo, we identify a new Drosophila APC homologue, E-APC. E-APC also binds to Shaggy, the Drosophila GSK-3 homologue. Interference with E-APC function produces embryonic phenotypes like those of shaggy mutants. Interestingly, E-APC is concentrated in apicolateral adhesive zones of epithelial cells, along with Armadillo and E-cadherin, which are both integral components of the adherens junctions in these zones. Various mutant conditions that cause dissociation of E-APC from these zones also obliterate the segmental modulation of free Armadillo levels that is normally induced by Wingless signalling. We propose that the Armadillo-destabilizing protein complex, consisting of E-APC, Shaggy, and a third protein, Axin, is anchored in adhesive zones, and that Wingless signalling may inhibit the activity of this complex by causing dissociation of E-APC from these zones. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Nat. Cell Biol. | ||
| Title | Nature Cell Biology | ||
| Publication Year | 1999- | ||
| ISBN/ISSN | 1465-7392 1476-4679 | ||
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Data from Reference
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| Alleles (11)
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| Constructs (2)
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| Genes (12)
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| Insertions (1)
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