Reference Report

Reference
Citation	Booth, G.E., Kinrade, E.F.V., Hidalgo, A. (2000). Glia maintain follower neuron survival during Drosophila CNS development. Development 127(2): 237--244. (Export to RIS)
FlyBase ID	FBrf0122973
Publication Type	Research paper
PubMed ID	10603342
PubMed Abstract	While survival of CNS neurons appears to depend on multiple neuronal and non-neuronal factors, it remains largely unknown how neuronal survival is controlled during development. Here we show that glia regulate neuronal survival during formation of the Drosophila embryonic CNS. When glial function is impaired either by mutation of the glial cells missing gene, which transforms glia toward a neuronal fate, or by targeted genetic glial ablation, neuronal death is induced non-autonomously. Pioneer neurons, which establish the first longitudinal axon fascicles, are insensitive to glial depletion whereas the later extending follower neurons die. This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (10)
	Avic\GFP^{Scer\UAS.T:Hsap\Myr2} BacA\p35^elav.PB Ecol\lacZ^{Scer\UAS.T:Btau\MAPT} gcm^ΔP1 Rcom\RA^Scer\UAS.cSa rpr^Scer\UAS.cJa Scer\GAL4¹⁵⁸ Scer\GAL4^C321c Scer\GAL4^s.gcm w^+mC
Constructs (6)
	P{elav-p35.B} P{sgcm-GAL4} P{UAS-gapGFP} P{UAS-RA} P{UAS-rpr.J} P{UAS-tau-lacZ.B}
Genes (18)
	Avic\GFP BacA\p35 Btau\MAPT crq Ecol\lacZ elav eve Fas2 futsch gcm odd Rcom\RA repo rpr Scer\GAL4 T:Btau\MAPT T:Hsap\Myr2 w
Insertions (6)
	P{elav-p35.B}9.1 P{elav-p35.B}10.4 P{GAL4}158 P{GawB}C321c P{sgcm-GAL4}151 P{sgcm-GAL4}211