Reference Report

Reference
Citation	Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. (1999). Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99(7): 803--815. (Export to RIS)
FlyBase ID	FBrf0122981
Publication Type	Research paper
PubMed ID	10619433
PubMed Abstract	Members of the Hedgehog (Hh) family of secreted signaling proteins function as potent short-range organizers in animal development. Their range of action is limited by a C-terminal cholesterol tether and the upregulation of Patched (Ptc) receptor levels. Here we identify a novel segment-polarity gene in Drosophila, dispatched (disp), and demonstrate that its product is required in sending cells for normal Hh function. In the absence of Disp, cholesterol-modified but not cholesterol-free Hh is retained in these cells, indicating that Disp functions to release cholesterol-anchored Hh. Despite their opposite roles, Disp and Ptc share structural homology in the form of a sterol-sensing domain, suggesting that release and sequestration of cholesterol-modified Hh may be based on related molecular pathways.
DOI
Related Publication(s)
Review	Paper alert. Jones, 2000, Curr. Opin. Genet. Dev. 10(2): 134 [FBrf0126742] Paper alert. Tsang, 2000, Curr. Opin. Genet. Dev. 10(2): 136 [FBrf0126748]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (18)
	Avic\GFP^Scer\UAS.cYa disp^S037707 disp^{Scer\UAS.T:Ivir\HA1} disp^αTub84B.PB Ecol\lacZ^dpp-10638 Ecol\lacZ^hh-P30 Ecol\lacZ^ptc.10.8L Fas1::hh^GPI.Scer\UAS Fas1::hh^{ΔGPI.Scer\UAS} hh^AC hh^{N.Scer\UAS.T:Ivir\HA1} hh^{Scer\UAS.T:Ivir\HA1} hh^{SF.Scer\UAS.T:Rnor\CD2} hh^ts2 Scer\GAL4^Act5C.PP Scer\GAL4^en-e16E Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} w^+mC
Constructs (11)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{hhCD2} P{ptc-lacZ.10.8L} P{UAS-disp.HA1} P{UAS-GFP.Y} P{UAS-hh::Fas1.GPI} P{UAS-hh::Fas1.ΔGPI} P{UAS-hh.F.HA} P{UAS-hh.N.HA} P{αTub84B-disp.B}
Genes (12)
	Avic\GFP disp Ecol\lacZ Fas1::hh hh Npc1a ptc Scer\GAL4 shg T:Ivir\HA1 T:Rnor\CD2 w
Insertions (4)
	P{en2.4-GAL4}e16E P{lacW}disp^S037707 P{PZ}dpp¹⁰⁶³⁸ P{PZ}hh^P30