Reference Report

Reference
Citation	Goberdhan, D.C.I., Paricio, N., Goodman, E.C., Mlodzik, M., Wilson, C. (1999). Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev. 13(24): 3244--3258. (Export to RIS)
FlyBase ID	FBrf0123020
Publication Type	Research paper
PubMed ID	10617573
PubMed Abstract	The human tumor suppressor gene PTEN encodes a putative cytoskeleton-associated molecule with both protein phosphatase and phosphatidylinositol 3,4,5-trisphosphate (PIP3) 3-phosphatase activities. In cell culture, the lipid phosphatase activity of this protein is involved in regulating cell proliferation and survival, but the mechanism by which PTEN inhibits tumorigenesis in vivo is not fully established. Here we show that the highly evolutionarily conserved Drosophila PTEN homolog, DPTEN, suppresses hyperplastic growth in flies by reducing cell size and number. We demonstrate that DPTEN modulates tissue mass by acting antagonistically to the Drosophila Class I phosphatidylinositol 3-kinase, Dp110, and its upstream activator Chico, an insulin receptor substrate homolog. Surprisingly, although DPTEN does not generally affect cell fate determination, it does appear to regulate the subcellular organization of the actin cytoskeleton in multiple cell types. From these data, we propose that DPTEN has a complex role in regulating tissue and body size. It acts in opposition to Dp110 to control cell number and growth, while coordinately influencing events at the cell periphery via its effects on the actin cytoskeleton.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (3)
	Df(2L)41C Df(2L)flp147E Df(2L)flp170B
Alleles (19)
	bsk^flp147E chico¹ chico^41C chico^170B chico^flp147E Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} Pi3K92E^{Scer\UAS.T:Hsap\MYC} Pten¹ Pten³ Pten^+t6.3 Pten^hs.PG Pten^Scer\UAS.cGa Ror^41C Scer\GAL4^Bx-MS1096 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E w^+mC w^+mW.hs
Constructs (7)
	P{Dp110^D954A} P{Dp110-CAAX} P{GAL4-dpp.blk1} P{hs-Pten.G} P{Pten.6.3.vivI} P{UAS-Pten.G} P{WT-Dp110}
Genes (9)
	bsk chico Pi3K92E Pten Ror Scer\GAL4 T:Hsap\CAAX T:Hsap\MYC w
Insertions (2)
	P{en2.4-GAL4}e16E P{GawB}Bx^MS1096
Transcripts (2)
	Pten-RA Pten-RB